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Methods We administered ternary Spike HexaPro formulated in a cationic liposomal adjuvant as a parenteral (subcutaneous – sc) initial – intranasal booster regimen to elicit airway mucosal immune responses and evaluated it in a Syrian hamster virus transmission model. Foundings Parenteral priming – intranasal boosting induced high-magnitude neutralizing serum antibody and IgA responses in the upper respiratory tract. The vaccine strategy protected against virus in the lower airways and lung pathology, but virus could be detected in the upper airways....

During a bellicose speech at an economic conference in Vladivostok, Putin said he would talk to Turkish President Recep Tayyip Erdogan about “restricting grain export destinations”, falsely claiming that only two of the 87 ships leaving Ukraine with grain had gone to developing countries. The divisive remarks came during a speech in which Putin also threatened to cut off all gas, oil and coal deliveries to Europe if they imposed a price cap on Russian energy imports....

The 96-year-old invited the conservative politician to Balmoral Castle in Scotland on Tuesday, where she formally asked her to form a new government after Boris Johnson resigned. The Queen has appointed 14 prime ministers during her 70-year reign, with ceremonies usually held at Buckingham Palace. Tuesday marked the first time Her Majesty has appointed a prime minister in Scotland, amid speculation she was too frail to travel back to England for the ceremony....

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Cette situation est causée par l’expiration des mesures de protection temporaires prévues pour le 24 septembre. «C’est officiel, on revient à une loi normale sur l’assurance-emploi», a déclaré Mme Sirois, qui a dénoncé l’inaction du gouvernement canadien, qui devait ajouter plus de mesures pour soutenir les chômeurs. La réforme en profondeur du régime d’assurance-emploi traîne encore en longueur, ce qui n’est pas réjouissant. “Il n’y a pas d’évolution dans le dossier”, révèle Mme Sirois....

Police said they received a report that the two suspects, identified by RCMP as Damien Sanderson and Myles Sanderson, may have been traveling in the Arcola Avenue area in Regina around 11:45 a.m. “As the suspects are at large, we have also asked for the alert to be extended to Manitoba and Alberta,” RCMP said in a news release Sunday afternoon. They released that information just after noon CT Sunday....

If you’re looking for something fun to do as a last hurray for summer, here’s what you need to know about what’s open and closed on Monday. WHAT IS OPEN Most tourist attractions including CNE, Canada’s Wonderland, CN Tower, Ontario Science Centre, Ripley’s Aquarium, Royal Ontario Museum, Casa Loma, Ontario Art Gallery and the Zoo Toronto. Some malls such as Eaton Centre, Square One, Vaughan Mills, Toronto Premium Outlets and Pacific Mall....

L’ancienne députée Sira Sylla, élue en 2017 sous l’étiquette La République en marche, a été condamnée mardi 6 septembre par le conseil des prud’hommes de Rouen pour harcèlement moral d’une ancienne députée, à qui elle doit par ailleurs 76.000 euros. Le conseil « constate que les multiples SMS envoyés par Mme Sira Sylla » à la plaignante « contiennent des menaces répétées de sanctions, des propos désobligeants, des critiques sur sa pathologie », selon la décision de justice consultée sur place par l’Agence France-Presse (AFP)....

Nachrichtencrawler-Aufnahmen auf der Website zeigen große Mengen Blut auf der Plattform. Nach Angaben des Augenzeugen wurde gegen 19 Uhr eine Person mit einem Messer angegriffen. Laut dem News-Scout handelt es sich bei dem Stürmer um einen 17-Jährigen, den er kennt. Auslöser der Eskalation soll ein früherer Streit um die Portokasse gewesen sein, bei dem der 17-Jährige ein Messer zog und auf den Mann einstach. Die Polizei ist mit mehreren Einsatzfahrzeugen vor Ort, Rettungskräfte wurden bereits gerufen....

The prime minister is accused of making appointments to reward long-standing friendships and loyalty in the leadership contest, rather than ability. Coffey said it was the most diverse cabinet ever. “Many of the people who are taking on roles will show that they have been taken into account, that they have been competent and compassionate in the way they have approached policy,” he told BBC Radio 4’s Today programme. “I know Liz,” she said – before adding that she now has to remind herself to call her friend Prime Minister – “is very keen to ensure we have a focused delivery and we believe we can go ahead and deliver on the plan she has set out ....

Her Highland estate – every purple-hued bough filled with memories of her beloved Philip – was a huge source of comfort after the hardest of times. A source with close ties to the Royal Family recently told me that he was not suffering from any chronic condition. Another said: “She’s lost a lot of weight and feels all the pains you’d expect a 96-year-old woman to feel and has been having terrible problems with her sore legs....

Gwent Police Detective Chief Constable Marc Budden, Detective Chief Inspector Paul Staniforth and former Chief Inspector Mark Warrender all attended the event held for a former chief constable in Cardiff city center in June 2019. Mr Warrender was charged with a sexual offense against a female officer, while Mr Budden and Mr Staniforth faced misconduct charges. During misconduct hearings held between April 7 and September 6, it emerged that Mr Warrender had inappropriately touched the officer....

Tim Michels, who co-owns the state’s largest construction company, faces Democratic Gov. Tony Evers in the battleground. If Michels wins, he will be able to enact a number of GOP priorities passed by the Republican-controlled Legislature leading up to the 2024 presidential election. Evers has vetoed more bills than any governor in modern history. state and is campaigning on his ability to act as a check on Republicans. People also read… Michels, a multi-millionaire, reacted strongly this week to a story published by the Milwaukee Journal Sentinel detailing charitable giving from him and his wife’s foundation, some of which went to anti-abortion groups and churches that have taken anti-gay positions....

Police said a woman was jogging in the area of ​​Dupont Street and Edwin Avenue when an unknown man came out of the bushes and allegedly exposed himself. He then took a few steps toward the woman, but she ran away, police said. On Saturday afternoon, police released photos of the suspect. He is believed to be in his 30s and is described as six feet tall with a thin build, heavily tanned skin and black facial hair....

Lenin is the pseudonym of a Russian soldier whose name is unknown but whose grim experience was recounted by one of his confidants in a September 5 phone call intercepted by a Western intelligence agency. Yahoo News was unable to independently verify the identity of the speakers or what caused the described massacre. But the anecdote has been watching what Russian soldiers and their increasingly frustrated boosters have been saying for days on social media....

On Wednesday night, Mr. Biden took the stage at Independence National Historical Park in Philadelphia, Pennsylvania, to deliver a rare and direct rebuke to his predecessor and his supporters who, he said, “represent an extremism that threatens the very foundations of our Republic”. Right-wing media circles and politicians were quick to respond to Mr Biden’s speech, calling it dictatorial and providing alleged proof that the Democrat had declared war on “Red State America”....

The Russian president added that all of the Kremlin’s actions – which he calls a special military operation – were designed to strengthen his country’s sovereignty and were aimed at “helping the people” living in eastern Ukraine’s Donbass region. It comes after military analysts said Russia had failed in its original goal of capturing Kyiv in a “lightning strike” move and that the country has lost thousands of troops and military hardware....

The Security Service of Ukraine has announced that it has arrested a woman for leaking military information. The unnamed woman tapped her soldier husband for information and leaked it to a Russian soldier. She was reportedly promised Russian citizenship and a high standard of living when they occupied the region. The Security Service of Ukraine (SBU) has announced that it has arrested a woman for revealing to Russian forces the location of her husband’s military unit and other military information....

Nachdem das Fahrzeug weggefahren war, schlugen und traten mehrere Männer der Gruppe den 32-Jährigen mit Fäusten und Füßen. Ein Mitglied der Gruppe versprühte auch eine brennbare Flüssigkeit und zündete sie an, wodurch das Opfer Verbrennungen und Prellungen erlitt. Als ein Passant und ein Autofahrer an der Bushaltestelle anhielten, flüchteten die Unbekannten in Richtung Zentrum von Winterthur-Seine. Ein Rettungsteam rückte sofort aus, um die Verletzten zu versorgen. Anschließend wurde er mit dem Rettungswagen ins Krankenhaus gebracht....

Ukrainian President Volodymyr Zelenskyy warned of a near “radiation disaster” as a fire forced the shutdown of the last active reactor at Ukraine’s Zaporizhzhia nuclear power plant, hours before the UN nuclear watchdog was due to brief the Security Council on its assessment of status. to the point. Ukraine and Russia have accused each other of risking disaster by shelling near the factory, which Russian troops seized soon after launching their invasion of Ukraine on February 24....